Panacur (fenbendazole) Paste 10% contains the active anthelmintic, fenbendazole. Each gram of Panacur Paste contains 100 mg of fenbendazole and is flavored with artificial apple-cinnamon liquid. Administer 1 syringe per 1,250 lbs. daily for 5 consecutive days. Actions: The antiparasitic action of Panacur Paste 10% is believed to be due to the inhibition of energy metabolism in the parasite. Indications: Panacur Paste is indicated for the control of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), encysted early third stage (hypobiotic), late third stage and fourth stage cyathostome larvae, small strongyles, pinworms (Oxyuris equi), ascarids (Parascaris equorum), and arteritis caused by fourth stage larvae of Stongylus vulgaris in horses. Panacur Paste 10% is approved for use concomitantly with an approved form of trichlorfon. Trichlorfon is approved for the treatment of stomach bots (Gasterophilus spp.) in horses. Refer to the manufacturer's label for directions for use and cautions for trichlorfon. Contraindictions: There are no known contraindications for the use of Panacur Paste 10% in horses. Precautions: Side effects associated with Panacur Paste 10% could not be established in well-controlled safety studies in horses with single doses as high as 454 mg/lb. (1,000 mg/kg) and 15 consecutive daily doses of 22.7 mg/lb. (50 mg/kg). Particularly with higher doses, the lethal action of fenbendazole may cause the release of antigens by the dying parasites. This phenomenon may result in either a local or systemic hypersensitive reaction. As with any drug, these reactions should be treated symptomatically. Panacur Paste 10% has been evaluated for safety in pregnant mares during all stages of gestation with doses as high as 11.4 mg/lb. (25 mg/kg) and in stallions with doses as high as 11.4 mg/lb. (25 mg/kg). No adverse effects on reproductively were detected. The recommended dose for control of
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